Across TCGA patient cohorts, POTEE mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible POTEE-associated genes across cancer lineages are Cyclin-B1, MYH11, and p70-S6K. Each is linked with POTEE in more than 4 cancer types. Because this analysis shows association rather than direction, both POTEE-to-partner and partner-to-POTEE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEE→partner) and Y-score (partner→POTEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.535	+3.459	.008	.005	3	5
LUSC	MYH11 →	-1.055	-2.450	.009	.019	3	3
LUSC	p70-S6K →	+0.237	+3.000	.025	.033	3	3
LUSC	Chk2 →	+0.310	+2.468	.008	.011	3	3
UCEC	JNK2 →	+0.164	+1.584	.021	.019	3	3
SKCM	MIG-6 →	+0.128	+1.762	.028	.049	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

POTEE survival (RNA) · tumor vs normal (RNA) · all POTEE data types