Across TCGA cell cohorts, POTEE mutation is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POTEE-associated genes across cancer lineages are ULBP1, TBX18, and NGLY1. Each is linked with POTEE in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEE-to-partner and partner-to-POTEE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEE→partner) and Y-score (partner→POTEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ULBP1 →	+1.079	+3.212	.001	.006	3	2
LARGE_INTESTINE	TBX18 →	+1.337	+3.228	<.001	.009	3	2
LARGE_INTESTINE	NGLY1 →	+0.395	+3.064	.007	.009	3	2
LUNG_NSCLC_LUAD	IQCF1 →	+0.103	+3.554	.002	.002	3	2
LUNG_NSCLC_LUAD	PRSS55 →	+0.022	+3.078	<.001	.004	3	2
BLOOD_Lymphoma	TAS2R7 →	+0.032	+5.643	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

Exploration

POTEE survival (RNA) · tumor vs normal (RNA) · all POTEE data types