Across TCGA patient cohorts, POTEC mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POTEC-associated genes across cancer lineages are 4E-BP1, CDK1, and FoxM1. Each is linked with POTEC in more than 2 cancer types. Because this analysis shows association rather than direction, both POTEC-to-partner and partner-to-POTEC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEC→partner) and Y-score (partner→POTEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.222	+1.351	.012	.042	3	3
SKCM	CDK1 →	+0.183	+3.000	.012	.035	3	3
LUAD	FoxM1 →	+0.251	+2.334	.028	.018	2	3
LUAD	MSH6 →	+0.463	+3.338	<.001	.004	3	2
LUAD	53BP1 →	+0.284	+2.824	.029	.034	3	2
UCEC	Ku80 →	+0.159	+1.405	.040	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

POTEC survival (RNA) · tumor vs normal (RNA) · all POTEC data types