Across TCGA cell cohorts, POTEC mutation is significantly associated with the drug of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POTEC-associated genes across cancer lineages are LCL161, Wee1 Inhibitor, and PLK_6522. Each is linked with POTEC in more than 1 cancer types. Because this analysis shows association rather than direction, both POTEC-to-partner and partner-to-POTEC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POTEC→partner) and Y-score (partner→POTEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.437	+2.646	.006	.047	3	2
LARGE_INTESTINE	Wee1 Inhibitor →	+0.538	+2.710	.042	.027	3	1
LARGE_INTESTINE	PLK_6522 →	+0.680	+2.649	.039	.046	3	1
LARGE_INTESTINE	VE-822 →	+0.661	+2.646	.020	.047	3	1
LARGE_INTESTINE	Mirin →	+0.380	+2.646	.045	.047	2	1
LARGE_INTESTINE	Uprosertib →	+0.694	+2.646	.021	.047	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

POTEC survival (RNA) · tumor vs normal (RNA) · all POTEC data types