Across TCGA pan-cancer cohorts, POT1-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated POT1-AS1 data layer compared with 1 for mutation status.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher POT1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated POT1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and SKCM show a favorable association.
ACC, STAD, and KIRP are the cancer types where POT1-AS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.