PORCN

Across TCGA pan-cancer cohorts, PORCN Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PORCN data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PORCN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PORCN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BLCA, UCEC, and HNSC are the cancer types where PORCN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.249	0.711	.003	39	view →
UCEC	DFS	Median	All	1.000	0.622	.004	28	view →
HNSC	OS	Median	II,III,IV	0.196	0.710	.023	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PORCN–BLCA (OS)

Open the BLCA breakdown →