POR

Across TCGA cell cohorts, POR protein abundance is significantly associated with the go_rna of many other GO terms, with 3,009 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POR-associated GO terms across cancer lineages are Mitochondrion-endoplasmic reticulum membrane tethering, Heme biosynthetic process, and Response to alcohol. Each is linked with POR in more than 6 cancer types. Because this analysis shows association rather than direction, both POR-to-partner and partner-to-POR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrion-endoplasmic reticulum membrane tethering grouped by POR-low versus POR-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POR→partner) and Y-score (partner→POR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.115	+0.687	<.001	<.001	3	7
BLOOD_Lymphoma	Heme biosynthetic process →	+0.095	+0.833	<.001	<.001	3	6
BLOOD_Lymphoma	Response to alcohol →	+0.066	+0.778	<.001	<.001	3	6
BLOOD_Lymphoma	Pigment biosynthetic process →	+0.098	+1.034	<.001	<.001	3	6
BREAST	Mitochondrial potassium ion transmembrane transport →	+0.088	+0.620	<.001	<.001	3	5
OVARY	Secondary alcohol metabolic process →	+0.101	+0.821	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,009 associations by consensus.

Mitochondrion-endoplasmic reticulum membrane tethering by POR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →