POR

Across TCGA cell cohorts, POR mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POR-associated genes across cancer lineages are H2BW1, UGT2B28, and OR1M1. Each is linked with POR in more than 1 cancer types. Because this analysis shows association rather than direction, both POR-to-partner and partner-to-POR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by POR-low versus POR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POR→partner) and Y-score (partner→POR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BW1 →	+0.022	+4.977	<.001	.002	3	1
SOFT_TISSUE	UGT2B28 →	+0.113	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1M1 →	+0.056	+5.515	<.001	<.001	3	1
SOFT_TISSUE	OBP2B →	+0.108	+4.369	<.001	.008	3	1
SOFT_TISSUE	CT45A6 →	+0.019	+4.369	<.001	.008	3	1
BREAST	SIGLEC5 →	+0.015	+4.312	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

H2BW1 by POR expression — SOFT_TISSUE

Explore this box plot interactively →