POPDC3

Across TCGA cell cohorts, POPDC3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible POPDC3-associated genes across cancer lineages are OPRPN, GML, and LGI1. Each is linked with POPDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both POPDC3-to-partner and partner-to-POPDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by POPDC3-low versus POPDC3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POPDC3→partner) and Y-score (partner→POPDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.088	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	HCRTR2 →	+0.013	+4.551	<.001	.004	3	1
BLOOD_Leukemia	KERA →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	LRIT1 →	+0.046	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OPRPN by POPDC3 expression — URINARY_TRACT

Explore this box plot interactively →