POPDC2

Across TCGA patient cohorts, POPDC2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POPDC2-associated genes across cancer lineages are Notch1, eEF2, and A-Raf_pS299. Each is linked with POPDC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POPDC2-to-partner and partner-to-POPDC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by POPDC2-low versus POPDC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POPDC2→partner) and Y-score (partner→POPDC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.185	+2.807	.002	.003	3	2
UCEC	eEF2 →	+0.418	+3.169	.007	.018	3	1
UCEC	A-Raf_pS299 →	-0.188	-3.584	<.001	.002	3	1
UCEC	ERK2 →	+0.234	+3.169	.005	.018	3	1
UCEC	GATA6 →	-0.170	-2.985	.018	.034	3	1
UCEC	JNK2 →	+0.326	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by POPDC2 expression — UCEC

Explore this box plot interactively →