POP5

Across TCGA pan-cancer cohorts, POP5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POP5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POP5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POP5 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

HNSC, COAD, and CCRCC are the cancer types where POP5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POP5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.261	<.001	8	view →
COAD	All	All	+0.388	.004	6	view →
CCRCC	Male	II,III,IV	−0.267	<.001	6	view →
LSCC	All	All	+0.154	.002	4	view →
LUAD	All	All	−0.138	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POP5–HNSC

Open the HNSC breakdown →