POP5

Across TCGA patient cohorts, POP5 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POP5-associated genes across cancer lineages are RN7SKP221, TRDD1, and MIR4665. Each is linked with POP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both POP5-to-partner and partner-to-POP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP221 grouped by POP5-low versus POP5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP5→partner) and Y-score (partner→POP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
UCEC	MIR4665 →	+1.090	+4.211	<.001	.009	3	1
UCEC	MIR4796 →	+0.662	+4.771	<.001	.006	3	1
UCEC	RNU6-7 →	+0.778	+4.398	<.001	.006	3	1
UCEC	RNA5SP97 →	+1.237	+4.326	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RN7SKP221 by POP5 expression — BRCA

Explore this box plot interactively →