POP5

Across TCGA cell cohorts, POP5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. CNS shows the largest number of these associations.

The most reproducible POP5-associated genes across cancer lineages are PRAMEF10 and NAT8B. Each is linked with POP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both POP5-to-partner and partner-to-POP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by POP5-low versus POP5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP5→partner) and Y-score (partner→POP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF10 →	+0.369	+5.754	<.001	.002	3	1
CNS	NAT8B →	+0.043	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PRAMEF10 by POP5 expression — CNS

Explore this box plot interactively →