POP1

Across TCGA patient cohorts, POP1 mutation is significantly associated with the RNA expression of many other genes, with 3,931 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POP1-associated genes across cancer lineages are CCNB2, HASPIN, and BUB3. Each is linked with POP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both POP1-to-partner and partner-to-POP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by POP1-low versus POP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP1→partner) and Y-score (partner→POP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCNB2 →	+0.636	+2.006	.007	.005	3	5
UCEC	HASPIN →	+0.619	+1.651	<.001	.001	3	5
SKCM	BUB3 →	+0.515	+2.508	<.001	.001	3	4
UCEC	SKA1 →	+0.587	+1.776	<.001	<.001	3	4
UCEC	TYMS →	+0.554	+1.901	.002	.004	3	4
UCEC	TIMM22 →	+0.337	+1.638	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,931 associations by consensus.

CCNB2 by POP1 expression — SKCM

Explore this box plot interactively →