POP1

Across TCGA patient cohorts, POP1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POP1-associated genes across cancer lineages are FASN, MEK1, and TFRC. Each is linked with POP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POP1-to-partner and partner-to-POP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by POP1-low versus POP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP1→partner) and Y-score (partner→POP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FASN →	+0.556	+3.000	.023	.036	3	3
UCEC	MEK1 →	+0.360	+2.502	<.001	.001	3	3
UCEC	TFRC →	+0.351	+1.584	.024	.032	3	3
LUSC	MSH2 →	+0.374	+2.816	.028	.036	3	2
SKCM	p53 →	+0.202	+1.891	.020	.030	3	2
UCEC	A-Raf_pS299 →	-0.073	-1.247	.038	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

FASN by POP1 expression — LUAD

Explore this box plot interactively →