POP1

Across TCGA cell cohorts, POP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,754 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POP1-associated GO terms across cancer lineages are DNA replication checkpoint signaling, DNA replication, and DNA-templated transcription termination. Each is linked with POP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both POP1-to-partner and partner-to-POP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by POP1-low versus POP1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POP1→partner) and Y-score (partner→POP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication checkpoint signaling →	+0.160	+1.200	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.120	+1.545	<.001	<.001	3	15
BONE	DNA-templated transcription termination →	+0.126	+1.193	.002	.002	3	15
LUNG_NSCLC_LUSC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.171	+1.320	<.001	<.001	3	14
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.174	+1.772	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.135	+1.545	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

DNA replication checkpoint signaling by POP1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →