POP1

Across TCGA cell cohorts, POP1 mutation is significantly associated with the RNA expression of many other genes, with 874 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POP1-associated genes across cancer lineages are GAR1, CCDC138, and DDX20. Each is linked with POP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POP1-to-partner and partner-to-POP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAR1 grouped by POP1-low versus POP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POP1→partner) and Y-score (partner→POP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAR1 →	+0.431	+3.352	.009	.004	3	2
LUNG_NSCLC_LUAD	CCDC138 →	+0.663	+3.206	<.001	.006	3	2
LUNG_NSCLC_LUAD	DDX20 →	+0.588	+3.206	<.001	.006	3	2
LARGE_INTESTINE	C1QBP →	+0.620	+2.588	.004	.004	3	2
LARGE_INTESTINE	RPF1 →	+0.742	+3.714	<.001	<.001	3	2
LARGE_INTESTINE	PPP1R8 →	+0.428	+3.125	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 874 associations by consensus.

GAR1 by POP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →