PON2

Across TCGA patient cohorts, PON2 mutation is significantly associated with the RNA expression of many other genes, with 2,005 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PON2-associated genes across cancer lineages are RN7SL275P, RN7SKP44, and MIR1255B2. Each is linked with PON2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PON2-to-partner and partner-to-PON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL275P grouped by PON2-low versus PON2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PON2→partner) and Y-score (partner→PON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL275P →	+0.152	+2.496	<.001	.003	3	2
HNSC	RN7SKP44 →	+0.136	+5.069	<.001	.008	3	2
UCEC	MIR1255B2 →	+0.257	+2.833	.003	.009	3	2
UCEC	RN7SKP286 →	+0.042	+3.890	<.001	.007	3	2
UCEC	RN7SL841P →	+0.093	+2.951	<.001	.007	3	2
UCEC	RNU7-81P →	+0.282	+2.951	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,005 associations by consensus.

RN7SL275P by PON2 expression — UCEC

Explore this box plot interactively →