POMT1

Across TCGA patient cohorts, POMT1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMT1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with POMT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both POMT1-to-partner and partner-to-POMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by POMT1-low versus POMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMT1→partner) and Y-score (partner→POMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.520	+2.999	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.261	-1.938	.001	.001	3	2
UCEC	eIF4E →	+0.168	+3.000	.015	<.001	3	2
UCEC	GAPDH →	+0.682	+2.263	<.001	<.001	3	2
UCEC	MEK1 →	+0.483	+2.584	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.134	-1.986	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eEF2 by POMT1 expression — UCEC

Explore this box plot interactively →