POMT1

Across TCGA cell cohorts, POMT1 mutation is significantly associated with the RNA expression of many other genes, with 750 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible POMT1-associated genes across cancer lineages are PRAMEF20, AWAT2, and TFDP3. Each is linked with POMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POMT1-to-partner and partner-to-POMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by POMT1-low versus POMT1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMT1→partner) and Y-score (partner→POMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	2
BLOOD_Lymphoma	AWAT2 →	+0.023	+3.342	<.001	.008	3	2
BLOOD_Leukemia	TFDP3 →	+0.006	+3.269	<.001	.007	3	2
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF14 →	+0.275	+4.523	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 750 associations by consensus.

PRAMEF20 by POMT1 expression — LUNG_SCLC

Explore this box plot interactively →