POMP

Across TCGA pan-cancer cohorts, POMP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POMP data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POMP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POMP expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where POMP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.909	1.000	.019	34	view →
UCEC	DFS	Quartile	All	0.961	0.802	.024	22	view →
LUAD	OS	Median	All	0.783	1.000	.009	9	view →
GBM	DFS	Tertile	All	0.415	0.277	.038	4	view →
PDAC	DFS	Median	IV	0.245	0.766	.017	3	view →
LSCC	DFS	Median	II,III,IV	0.866	0.695	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POMP–CCRCC (OS)

Open the CCRCC breakdown →