Across TCGA patient cohorts, POMK mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMK-associated genes across cancer lineages are eIF4E, Notch1, and PKC-delta_pS664. Each is linked with POMK in more than 1 cancer types. Because this analysis shows association rather than direction, both POMK-to-partner and partner-to-POMK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMK→partner) and Y-score (partner→POMK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.233	+2.321	.028	.035	3	2
UCEC	Notch1 →	+0.205	+2.820	.003	.035	3	2
UCEC	PKC-delta_pS664 →	-0.158	-2.321	.009	.035	3	2
UCEC	ATM →	-0.896	-3.169	<.001	.019	3	2
UCEC	ERK2 →	+0.259	+2.321	.007	.035	3	1
UCEC	Ku80 →	+0.362	+3.009	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

POMK survival (RNA) · tumor vs normal (RNA) · all POMK data types