POMGNT2

Across TCGA patient cohorts, POMGNT2 mutation is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMGNT2-associated genes across cancer lineages are OIP5, RPL23AP82, and WDHD1. Each is linked with POMGNT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POMGNT2-to-partner and partner-to-POMGNT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by POMGNT2-low versus POMGNT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMGNT2→partner) and Y-score (partner→POMGNT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.756	+1.947	<.001	.003	3	3
UCEC	RPL23AP82 →	+0.428	+3.008	<.001	<.001	3	3
UCEC	WDHD1 →	+0.575	+2.828	.002	<.001	3	3
UCEC	TIMM22 →	+0.350	+2.521	.002	.001	3	3
UCEC	CDKN3 →	+0.618	+2.230	.004	.006	3	3
UCEC	RFC5 →	+0.498	+3.593	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

OIP5 by POMGNT2 expression — UCEC

Explore this box plot interactively →