POMGNT1

Across TCGA patient cohorts, POMGNT1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMGNT1-associated genes across cancer lineages are p62 Lck ligand, Tuberin, and Caspase-7-cleavedD198. Each is linked with POMGNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both POMGNT1-to-partner and partner-to-POMGNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by POMGNT1-low versus POMGNT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMGNT1→partner) and Y-score (partner→POMGNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.325	+1.847	.006	.008	3	2
UCEC	Tuberin →	+0.290	+1.710	.003	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.501	+1.604	.021	.041	3	2
UCEC	14-3-3_beta →	-0.095	-2.558	.009	.010	3	1
UCEC	eEF2 →	+0.368	+1.502	.005	.030	3	1
UCEC	EGFR_pY1068 →	-0.307	-2.736	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p62 Lck ligand by POMGNT1 expression — UCEC

Explore this box plot interactively →