POMC

Across TCGA patient cohorts, POMC RNA expression is significantly associated with the protein abundance of many other proteins, with 13,343 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible POMC-associated proteins across cancer lineages are DOCK11, GIMAP8, and CD14. Each is linked with POMC in more than 4 cancer types. Because this analysis shows association rather than direction, both POMC-to-partner and partner-to-POMC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, POMC versus DOCK11 in BRCA, with a Pearson correlation of 0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (POMC→partner) and Y-score (partner→POMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOCK11 →	+0.356	+0.727	<.001	.001	3	5
GBM	GIMAP8 →	+0.453	+0.445	<.001	<.001	3	5
GBM	CD14 →	+0.460	+0.396	.004	.001	3	4
COAD	CD163 →	+0.633	+0.613	<.001	<.001	3	4
BRCA	CYBB →	+0.725	+0.596	<.001	.001	3	4
COAD	AKT3 →	+0.656	+0.588	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,343 associations by consensus.

POMC vs DOCK11 — BRCA

Explore this scatter interactively →