POMC

Across TCGA patient cohorts, POMC mutation is significantly associated with the RNA expression of many other genes, with 464 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMC-associated genes across cancer lineages are MT4, TEX43, and RPS27P27. Each is linked with POMC in more than 1 cancer types. Because this analysis shows association rather than direction, both POMC-to-partner and partner-to-POMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by POMC-low versus POMC-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMC→partner) and Y-score (partner→POMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MT4 →	+1.957	+3.833	<.001	.005	3	2
UCEC	TEX43 →	+0.241	+2.214	.001	.006	3	2
COAD	RPS27P27 →	+0.461	+3.842	.003	.005	3	2
CESC	LINC02272 →	+0.071	+5.584	<.001	.001	3	2
CESC	MIR3131 →	+1.247	+3.870	<.001	.002	3	2
HNSC	RPSAP35 →	+0.070	+5.303	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 464 associations by consensus.

MT4 by POMC expression — COAD

Explore this box plot interactively →