POMC

Across TCGA patient cohorts, POMC mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POMC-associated genes across cancer lineages are Myocytes, Chondrocytes, and Monocytes. Each is linked with POMC in more than 1 cancer types. Because this analysis shows association rather than direction, both POMC-to-partner and partner-to-POMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myocytes grouped by POMC-low versus POMC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POMC→partner) and Y-score (partner→POMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myocytes →	+0.047	+2.883	.002	.032	3	2
LUSC	Chondrocytes →	+0.015	+4.694	.004	.014	3	1
SKCM	Monocytes →	+0.009	+4.810	<.001	.043	3	1
UCEC	Erythrocytes →	+0.033	+2.818	.006	.035	3	1
UCEC	Th2 cells →	+0.221	+3.584	.011	.003	2	2

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Myocytes by POMC expression — UCEC

Explore this box plot interactively →