POMC

Across TCGA cell cohorts, POMC RNA expression is significantly associated with the go_rna of many other GO terms, with 649 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible POMC-associated GO terms across cancer lineages are Response to melanocyte-stimulating hormone, Regulation of translational initiation, and Nucleoside triphosphate biosynthetic process. Each is linked with POMC in more than 7 cancer types. Because this analysis shows association rather than direction, both POMC-to-partner and partner-to-POMC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to melanocyte-stimulating hormone grouped by POMC-low versus POMC-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POMC→partner) and Y-score (partner→POMC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to melanocyte-stimulating hormone →	+0.947	+2.520	.002	<.001	3	8
LUNG_SCLC	Regulation of translational initiation →	+0.060	+1.298	.002	.009	2	6
OVARY	Nucleoside triphosphate biosynthetic process →	+0.051	+0.093	.003	.002	2	5
OVARY	Translational initiation →	+0.056	+0.106	<.001	.002	3	4
OVARY	Establishment of protein localization to organelle →	+0.032	+0.119	.001	.008	3	4
LUNG_SCLC	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.082	-0.926	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 649 associations by consensus.

Response to melanocyte-stimulating hormone by POMC expression — LUNG_SCLC

Explore this box plot interactively →