POM121L2

Across TCGA patient cohorts, POM121L2 mutation is significantly associated with the RNA expression of many other genes, with 2,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POM121L2-associated genes across cancer lineages are NCR1, CRYBB2P1, and LMF2. Each is linked with POM121L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both POM121L2-to-partner and partner-to-POM121L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCR1 grouped by POM121L2-low versus POM121L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121L2→partner) and Y-score (partner→POM121L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCR1 →	+0.292	+1.669	<.001	.001	3	3
UCEC	CRYBB2P1 →	+0.497	+1.879	<.001	<.001	3	2
UCEC	LMF2 →	+0.383	+3.073	<.001	<.001	3	2
UCEC	RHBDD3 →	+0.364	+2.662	.001	<.001	3	2
UCEC	GZMH →	+0.976	+2.699	<.001	<.001	3	2
UCEC	ADNP2 →	+0.470	+2.288	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

NCR1 by POM121L2 expression — UCEC

Explore this box plot interactively →