POM121L2

Across TCGA patient cohorts, POM121L2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POM121L2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and mTOR_pS2448. Each is linked with POM121L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both POM121L2-to-partner and partner-to-POM121L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by POM121L2-low versus POM121L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121L2→partner) and Y-score (partner→POM121L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.103	-2.388	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.058	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.111	-1.687	.019	.040	3	2
UCEC	Shc_pY317 →	-0.186	-2.906	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.715	+2.107	<.001	.002	3	2
UCEC	4E-BP1 →	+0.258	+1.700	.002	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

14-3-3_beta by POM121L2 expression — UCEC

Explore this box plot interactively →