Across TCGA patient cohorts, POM121L12 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible POM121L12-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with POM121L12 in more than 3 cancer types. Because this analysis shows association rather than direction, both POM121L12-to-partner and partner-to-POM121L12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POM121L12→partner) and Y-score (partner→POM121L12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAPDH →	+0.477	+1.652	.004	.005	3	4
COAD	Caspase-7-cleavedD198 →	+1.575	+3.016	<.001	.018	3	4
LUSC	Cyclin-E2 →	+0.098	+2.188	.040	.031	3	4
UCEC	Cyclin-B1 →	+0.475	+1.584	.007	.005	3	4
LUAD	MSH6 →	+0.271	+1.338	.003	.038	3	3
LUAD	Akt_pS473 →	-0.407	-1.938	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

POM121L12 survival (RNA) · tumor vs normal (RNA) · all POM121L12 data types