Across TCGA pan-cancer cohorts, POM121 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POM121 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher POM121 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POM121 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, GBM, and LUAD are the cancer types where POM121 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.991	0.569	.004	16	view →
GBM	DFS	Median	All	0.642	0.787	.014	7	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.583	.025	4	view →
PDAC	OS	Tertile	All	0.634	0.359	.029	4	view →
CCRCC	OS	Quartile	All	0.801	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: POM121 tumor-vs-normal RNA expression · all POM121 data types