POLR3K

Across TCGA pan-cancer cohorts, POLR3K mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR3K data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher POLR3K mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR3K expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where POLR3K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.845	0.612	.020	14	view →
CCRCC	OS	Tertile	All	1.000	0.063	.024	8	view →
GBM	DFS	Tertile	All	0.637	0.833	.008	6	view →
LUAD	OS	Median	All	0.971	0.767	.012	3	view →
PDAC	OS	Median	III,IV	0.656	0.386	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLR3K–LSCC (DFS)

Open the LSCC breakdown →