POLR3K

Across TCGA pan-cancer cohorts, POLR3K mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of POLR3K’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where POLR3K mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types POLR3K is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, LSCC, and CCRCC are the cancer types where POLR3K tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3K mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.362	<.001	8	view →
LSCC	Female	All	+0.293	<.001	8	view →
CCRCC	Female	All	+0.247	.001	4	view →
PDAC	All	All	−0.199	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

POLR3K–HNSC

Open the HNSC breakdown →