POLR3K

Across TCGA cell cohorts, POLR3K RNA expression is significantly associated with the go_rna of many other GO terms, with 5,488 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible POLR3K-associated GO terms across cancer lineages are DNA replication initiation, Cellular response to cisplatin, and rRNA pseudouridine synthesis. Each is linked with POLR3K in more than 18 cancer types. Because this analysis shows association rather than direction, both POLR3K-to-partner and partner-to-POLR3K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by POLR3K-low versus POLR3K-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3K→partner) and Y-score (partner→POLR3K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.206	+1.133	.001	<.001	3	19
SOFT_TISSUE	Cellular response to cisplatin →	+0.257	+0.804	.006	<.001	3	18
BONE	rRNA pseudouridine synthesis →	+0.185	+1.144	<.001	<.001	3	18
BONE	Termination of RNA polymerase III transcription →	+0.161	+1.141	<.001	<.001	3	18
BONE	DNA replication checkpoint signaling →	+0.197	+0.863	<.001	<.001	3	16
LIVER	rRNA 5'-end processing →	+0.175	+1.103	.002	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,488 associations by consensus.

DNA replication initiation by POLR3K expression — BONE

Explore this box plot interactively →