POLR3GP1

Across TCGA pan-cancer cohorts, POLR3GP1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of POLR3GP1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where POLR3GP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types POLR3GP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

UCEC, STAD, and BRCA are the cancer types where POLR3GP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR3GP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.265	.006	6	view →
STAD	All	All	+0.744	<.001	5	view →
BRCA	All	All	+0.259	.006	4	view →
THCA	All	All	−0.099	.005	4	view →
CHOL	All	All	+0.503	<.001	3	view →
LUAD	Female	All	+0.410	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

POLR3GP1–UCEC

Open the UCEC breakdown →