POLR3F

Across TCGA pan-cancer cohorts, POLR3F mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated POLR3F data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POLR3F mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR3F expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

UCEC, LUAD, and GBM are the cancer types where POLR3F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.411	1.000	.002	22	view →
LUAD	OS	Quartile	All	0.982	0.351	.002	20	view →
GBM	DFS	Quartile	All	0.448	0.256	.004	9	view →
LSCC	DFS	Median	II,III,IV	0.823	0.566	.013	3	view →
CCRCC	DFS	Tertile	All	0.691	1.000	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

POLR3F–UCEC (DFS)

Open the UCEC breakdown →