POLR3E

Across TCGA pan-cancer cohorts, POLR3E mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated POLR3E data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLR3E mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR3E expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where POLR3E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.804	0.238	<.001	26	view →
HNSC	DFS	Tertile	III,IV	0.890	1.000	.021	24	view →
LSCC	DFS	Tertile	All	0.851	0.571	.007	15	view →
CCRCC	DFS	Tertile	III,IV	0.704	1.000	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

POLR3E–LUAD (DFS)

Open the LUAD breakdown →