Across TCGA patient cohorts, POLR3C mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3C-associated genes across cancer lineages are eEF2, Acetyl-a-Tubulin-Lys40, and Ku80. Each is linked with POLR3C in more than 1 cancer types. Because this analysis shows association rather than direction, both POLR3C-to-partner and partner-to-POLR3C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3C→partner) and Y-score (partner→POLR3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.399	+2.459	.020	.020	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.533	+2.459	.030	.020	3	1
UCEC	Ku80 →	+0.273	+3.598	.016	.001	3	1
UCEC	Shc_pY317 →	-0.175	-3.000	.017	.036	3	1
UCEC	STAT3_pY705 →	-0.347	-2.999	.006	.035	3	1
UCEC	ERK2 →	+0.212	+2.459	.022	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

POLR3C survival (RNA) · tumor vs normal (RNA) · all POLR3C data types