POLR3B

Across TCGA pan-cancer cohorts, POLR3B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated POLR3B data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR3B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR3B expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where POLR3B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.328	0.889	.014	28	view →
UCEC	DFS	Median	II,III,IV	0.549	0.867	.046	4	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

POLR3B–HNSC (DFS)

Open the HNSC breakdown →