POLR3A

Across TCGA pan-cancer cohorts, POLR3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR3A data layer compared with 30 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher POLR3A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated POLR3A expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, HNSC, and LSCC are the cancer types where POLR3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.781	0.264	<.001	38	view →
HNSC	DFS	Median	III,IV	0.900	1.000	.003	31	view →
LSCC	DFS	Tertile	II,III,IV	0.907	0.526	.004	22	view →
PDAC	OS	Quartile	III,IV	0.673	0.201	.005	16	view →
CCRCC	OS	Quartile	All	0.336	1.000	.006	13	view →
GBM	DFS	Median	All	0.313	0.217	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR3A–LUAD (DFS)

Open the LUAD breakdown →