POLR3A

Across TCGA patient cohorts, POLR3A mutation is significantly associated with the RNA expression of many other genes, with 4,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible POLR3A-associated genes across cancer lineages are PAPLN, OIP5, and RNF167. Each is linked with POLR3A in more than 2 cancer types. Because this analysis shows association rather than direction, both POLR3A-to-partner and partner-to-POLR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAPLN grouped by POLR3A-low versus POLR3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR3A→partner) and Y-score (partner→POLR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAPLN →	-0.617	-1.484	.001	.001	3	3
UCEC	OIP5 →	+0.822	+1.699	<.001	<.001	3	3
UCEC	RNF167 →	+0.261	+1.966	.004	.002	3	3
UCEC	ZNF330 →	+0.315	+1.970	.002	<.001	3	3
UCEC	CPE →	-0.698	-1.652	.001	.005	3	3
STAD	GAPDH →	+0.751	+3.459	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,834 associations by consensus.

PAPLN by POLR3A expression — UCEC

Explore this box plot interactively →