POLR2M

Across TCGA pan-cancer cohorts, POLR2M Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated POLR2M data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher POLR2M Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2M expression acts as an unfavorable survival marker.

SKCM and UCEC are the cancer types where POLR2M Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.036	0.691	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

POLR2M–SKCM (DFS)

Open the SKCM breakdown →