POLR2M

Across TCGA pan-cancer cohorts, POLR2M mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated POLR2M data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher POLR2M mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated POLR2M expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where POLR2M mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.941	0.747	.004	11	view →
PDAC	DFS	Median	III,IV	0.309	0.930	.006	10	view →
LSCC	DFS	Tertile	II,III,IV	0.535	0.842	.032	3	view →
HNSC	DFS	Quartile	III,IV	0.631	0.848	.034	3	view →
GBM	DFS	Tertile	All	0.415	0.274	.047	2	view →
UCEC	DFS	Tertile	All	0.950	0.843	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

POLR2M–CCRCC (OS)

Open the CCRCC breakdown →