POLR2L

Across TCGA pan-cancer cohorts, POLR2L mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated POLR2L data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher POLR2L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated POLR2L expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where POLR2L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.311	1.000	.001	36	view →
CCRCC	OS	Median	All	0.897	1.000	.008	18	view →
LUAD	OS	Quartile	All	0.939	0.699	.023	18	view →
COAD	DFS	Median	All	1.000	0.891	.026	12	view →
GBM	OS	Tertile	All	0.460	0.255	.014	8	view →
PDAC	DFS	Quartile	All	0.918	0.777	.022	7	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.814	.011	4	view →
HNSC	DFS	Tertile	II,III,IV	0.579	0.802	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

POLR2L–UCEC (OS)

Open the UCEC breakdown →