POLR2L

Across TCGA pan-cancer cohorts, POLR2L mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of POLR2L’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where POLR2L mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types POLR2L is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where POLR2L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.389	<.001	9	view →
PDAC	Female	II,III,IV	−0.814	<.001	8	view →
LSCC	Male	II,III,IV	+0.272	<.001	5	view →
LUAD	All	All	+0.169	<.001	3	view →
CCRCC	All	All	+0.085	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

POLR2L–COAD

Open the COAD breakdown →