POLR2L

Across TCGA cell cohorts, POLR2L RNA expression is significantly associated with the go_rna of many other GO terms, with 3,951 significant associations in total. BONE shows the largest number of these associations.

The most reproducible POLR2L-associated GO terms across cancer lineages are GDP-mannose biosynthetic process, Keratinocyte development, and Protein depolymerization. Each is linked with POLR2L in more than 11 cancer types. Because this analysis shows association rather than direction, both POLR2L-to-partner and partner-to-POLR2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDP-mannose biosynthetic process grouped by POLR2L-low versus POLR2L-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2L→partner) and Y-score (partner→POLR2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GDP-mannose biosynthetic process →	+0.162	+1.277	<.001	.004	3	12
CNS	Keratinocyte development →	+0.423	+1.085	.001	<.001	3	11
BONE	Protein depolymerization →	+0.118	+1.197	.001	<.001	3	11
LARGE_INTESTINE	Positive regulation of early endosome to late endosome transport →	+0.138	+0.857	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of interleukin-4 production →	-0.207	-1.141	<.001	<.001	3	10
PANCREAS	Blood vessel maturation →	-0.397	-0.679	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,951 associations by consensus.

GDP-mannose biosynthetic process by POLR2L expression — URINARY_TRACT

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