POLR2KP1

Across TCGA pan-cancer cohorts, POLR2KP1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of POLR2KP1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where POLR2KP1 RNA is repressed in tumor relative to normal tissue. In most cancer types POLR2KP1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, COAD, and CHOL are the cancer types where POLR2KP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in POLR2KP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.659	<.001	6	view →
COAD	All	II,III,IV	+0.336	.003	4	view →
CHOL	Male	All	+1.166	<.001	3	view →
READ	All	All	+0.887	.010	3	view →
LUSC	Male	All	+0.516	<.001	3	view →
UCEC	All	III,IV	+0.565	.034	2	view →
LUAD	All	All	+0.375	.010	2	view →
LIHC	All	All	+0.126	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

POLR2KP1–THCA

Open the THCA breakdown →