POLR2K

Across TCGA pan-cancer cohorts, POLR2K mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated POLR2K data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher POLR2K mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated POLR2K expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and OV are the cancer types where POLR2K mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.563	0.870	.013	23	view →
LSCC	DFS	Median	II,III,IV	1.000	0.844	.010	20	view →
OV	DFS	Tertile	All	0.490	0.923	.032	16	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.811	.011	9	view →
PDAC	OS	Tertile	IV	0.905	0.231	.024	6	view →
GBM	DFS	Median	All	0.492	0.255	.018	3	view →
CCRCC	DFS	Median	All	0.740	0.870	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

POLR2K–HNSC (DFS)

Open the HNSC breakdown →