POLR2K

Across TCGA cell cohorts, POLR2K RNA expression is significantly associated with the go_rna of many other GO terms, with 2,780 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible POLR2K-associated GO terms across cancer lineages are Blastocyst growth, Somatic recombination of immunoglobulin gene segments, and Protein localization to kinetochore. Each is linked with POLR2K in more than 12 cancer types. Because this analysis shows association rather than direction, both POLR2K-to-partner and partner-to-POLR2K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Blastocyst growth grouped by POLR2K-low versus POLR2K-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (POLR2K→partner) and Y-score (partner→POLR2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Blastocyst growth →	+0.164	+0.647	.004	.002	2	13
URINARY_TRACT	Somatic recombination of immunoglobulin gene segments →	+0.071	+0.973	.002	<.001	3	10
BLOOD_Lymphoma	Protein localization to kinetochore →	+0.132	+0.855	<.001	<.001	3	9
URINARY_TRACT	Regulation of Notch signaling pathway →	-0.070	-0.558	.003	.004	2	10
BLOOD_Lymphoma	Protein localization to condensed chromosome →	+0.124	+0.842	<.001	<.001	3	8
BLOOD_Lymphoma	Protein localization to chromosome, centromeric region →	+0.099	+0.835	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,780 associations by consensus.

Blastocyst growth by POLR2K expression — LIVER

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